Posted by 445supermag

https://www.metafilter.com/210251/Woman-rescued-from-domestic-abuse-after-hand-signal-for-help

Someone in a 7-11 noticed that a woman gave the hand signal for help behind her back. Police were called, the man attempted to flee and was arrested on an open warrant and possession of a stun gun.

Besides verbal distress calls such as asking for an "Angel Shot" or calling 911 and ordering a pizza, the non-verbal hand signal was developed during the pandemic as a way to ask for help over video by the Canadian Women's Foundation. Since then, Guyana adopted it as a signal for human trafficking by gesturing three times.

https://www.metafilter.com/210251/Woman-rescued-from-domestic-abuse-after-hand-signal-for-help

Posted by chavenet

https://www.metafilter.com/210250/The-shots-heard-round-the-world

Fiction will always examine the small anonymous corners of human experience. But there is also the magnetic force of public events and the people behind them. There is something in the novel itself, its size and psychological reach, its openness to strong social themes, that suggests a matching of odd-couple appetites -- the solitary writer and the public figure at the teeming center of events. The writer wants to see inside the human works, down to dreams and routine rambling thoughts, in order to locate the neural strands that link him to men and women who shape history. Genius, ruthlessness, military mastery, eloquent self-sacrifice -- the coin of actual seething lives. from The Power of History by Don DeLillo [New York Times; ungated; published Sunday, September 7, 1997]

https://www.metafilter.com/210250/The-shots-heard-round-the-world

Posted by Wordshore

https://www.metafilter.com/210247/No-more-drugs

Bulk [trailer] [trailer] is a film by Ben Wheatley [A Field in England], narrated by Bill Nighy and starring Sam Riley and Alexandra Maria Lara. Variety: "...a film that is about nothing so much as its own diverse tapestry of influences, from the handmade whimsy of vintage TV series Thunderbirds to the opaquely minimalist sci-fi world-building of Godard's Alphaville to the luridly cranked-up paranoia of midcentury B-movies like The Quatermass Experiment." List: "Bulk's homespun flavour comes from Wheatley's deployment of old-school filmmaking techniques, from rear projection to false perspectives and model-making. For one scene, as helicopters streak across the sky, Wheatley used Airfix kits bought from eBay."

https://www.metafilter.com/210247/No-more-drugs

Posted by chavenet

https://www.metafilter.com/210245/What-if-a-newsroom-was-more-like-an-incubator

Given that incumbent newsrooms are failing, and platform-based independence comes with new risks, I don't think the solution is one or the other. Instead, it's worth trying to imagine a new kind of newsroom: one that meets the moment in terms of platform, trust, and voice, but provides the quality assurance, support, continuity, and opportunities for collaboration that newsrooms at their best provide. from When people trust humans more than brands: the incubator newsroom [Ben Werdmuller]

https://www.metafilter.com/210245/What-if-a-newsroom-was-more-like-an-incubator

Posted by chariot pulled by cassowaries

https://www.metafilter.com/210243/How-punks-played-Thatcherism-to-build-a-housing-co-operative-in-Hull

"Why not work the system?" How punks played Thatcherism to build a housing co-operative in Hull, Britain.

https://www.metafilter.com/210243/How-punks-played-Thatcherism-to-build-a-housing-co-operative-in-Hull

Posted by storybored

https://www.metafilter.com/210242/Where-are-the-Trillion-Dollar-Biotechs

The Dismal Economics of Bio-Tech Research. A long, detailed analysis of why biotech research is still hard. "Human genetics, drug repurposing, and AI are the most common levers [cited to improve things], and each promises to cut costs or derisk pipelines. But the more you look into specific companies and their stories, the more you notice that these strategies rarely work. This is especially true once you turn to age-related diseases, the only market large enough to rescue pharma's economics, yet the one where our best heuristics work the least."

"There are also plenty of examples of selecting a genetically validated target, often outside of oncology or CNS, and failing over and over again to deliver on the promise. CETP variant was enriched in centenarian cohorts and showed coronary heart disease reduction in people with the variant, yet 4 different drugs failed in early-stage trials (likely asset-specific failure). MSTN inhibition leads to obvious muscle mass gains, yet there were 4 failed MSTN antibodies before Scholar Rock got apitegromab approved earlier this year (indication/trial design failure). The list goes on and on. " --- "One number that is worth appreciating is that 80% of all costs associated with bringing a drug to market come from clinical-stage work. That is, if we ever get to molecules designed and preclinically validated in under 1 year, we'll be impacting only a small fraction of what makes drug discovery hard. This productivity gain cap is especially striking given that the majority of the data we can use to train models today is still preclinical, and, in most cases, even pre-animal. A perfect model predictive of in vitro tox saves you time on running in vitro tox (which is less than a few weeks anyway!), doesn't bridge the in vitro to animal translation gap, and especially does not affect the dreaded animal-to-human jump. As such, perfecting predictive validity for preclinical work is the current best-case scenario for the industry. Though we don't have a sufficient amount and types of data to solve even that. " --- Probability of Success by Clinical Trial Phase and Therapeutic Area. (P1 = Phase 1) Therapeutic AreaP1 to P2P2 to P3P3 to ApprovalOverall Oncology57.632.735.53.4 Metabolic/Endocrinology76.259.751.619.6 Cardiovascular73.365.762.225.5 Central Nervous System73.251.951.115.0 Autoimmune/Inflammation69.845.763.715.1 Genitourinary68.757.166.521.6 Infectious Disease70.158.375.325.2 Ophthalmology87.160.774.932.6 Vaccines (Infectious Disease)76.858.285.433.4 Overall66.448.659.013.8 Overall (Excluding Oncology)73.055.763.620.9

https://www.metafilter.com/210242/Where-are-the-Trillion-Dollar-Biotechs

Posted by chavenet

https://www.metafilter.com/210238/Music-the-occult-religion-and-geometry-math-were-all-connected-for-Co

Thelonious Monk once said "All musicians are subconsciously mathematicians". Musicians like John Coltrane though have been very much aware of the mathematics of music and consciously applied it to their works. The "Coltrane Circle" is (to me) proof of it in Coltrane's case ... from John Coltrane's Tone Circle [Roel's World]

https://www.metafilter.com/210238/Music-the-occult-religion-and-geometry-math-were-all-connected-for-Co